Hepatitas C yra virusas, sukeliantis lėtinį kepenų uždegimą ir ilgalaikę žalą. Dažniausiai jis plinta per užkrėstas adatas. HCV yra gydomas naujais antivirusiniais vaistais, tačiau daugelis žmonių nežino, kad yra užsikrėtę. Jie gali nejausti simptomų, kol kepenų liga progresuoja iki kepenų nepakankamumo.
Kas yra hepatitas C?
Hepatitas C yra virusinė infekcija, paveikianti kepenis. Ji sukelia uždegimą ir patinimą, kuris laikui bėgant pažeidžia kepenų audinius. „Hepatitas“ reiškia kepenų uždegimą. Hepatitas gali atsirasti dėl daugelio priežasčių, o kai kurios iš jų yra virusinės. Lyginant su kitomis virusinio hepatito priežastimis, hepatitas C daug dažniau lieka organizme ilgą laiką.
Lėtinis uždegimas, trunkantis daugelį metų, stipriai pažeidžia kepenis. Tiesą sakant, hepatitas C yra viena iš pagrindinių kepenų nepakankamumo ir kepenų transplantacijos priežasčių Jungtinėse Valstijose. Dauguma žmonių negali jausti, kad jų kepenys uždegusios, kol neatsiranda rimta žala.
Kaip dažnas yra hepatitas C?
JAV hepatito C infekcijos atvejų skaičius per pastarąjį dešimtmetį beveik keturis kartus padidėjo. Pasak Ligų kontrolės ir prevencijos centrų (CDC), šiuo metu Jungtinėse Valstijose beveik 4 milijonai žmonių gali būti užsikrėtę hepatitu C. Daugelis to nežino. Pasauliniu mastu užsikrėtusiųjų skaičius siekia 60 milijonų.
Kokia yra pagrindinė hepatito C priežastis?
Hepatitą C sukelia virusas, kuris plinta per kontaktą su krauju. Infekcija perduodama, kai užsikrėtusio asmens kraujas patenka į sveiko žmogaus organizmą. JAV tai dažniausiai nutinka, kai žmonės dalijasi adatomis intraveniniams narkotikams švirkšti. Pasauliniu mastu infekcija dažnai perduodama medicinos įstaigose, naudojant nesterilizuotus instrumentus.
Kuo skiriasi hepatitas A, B ir C?
Hepatitas A ir hepatitas B yra kiti virusai, taip pat sukeliantys hepatitą. Jie skiriasi užsikrėtimo būdais, infekcijos tipais, kuriuos sukelia, bei gydymo ir prevencijos metodais. Pagrindiniai skirtumai:
Tipas | Prevencija | Perdavimas | Infekcija | Gydymas |
---|---|---|---|---|
Hepatitas A | Turi vakciną | Per išmatas | Tik ūminė. Pasveikstama per kelias savaites. | Gydymas gali būti nereikalingas. Vakcina padeda, jei nebuvo skiepyta. |
Hepatitas B | Turi vakciną | Per kraują | Lėtinė tik 5% suaugusiųjų, bet 30% vaikų iki 5 metų amžiaus. | Antivirusiniai vaistai gali padėti kontroliuoti lėtinę infekciją, bet jos neišgydo. |
Hepatitas C | Nėra vakcinos | Per kraują | Lėtinė 80% žmonių. | Antivirusiniai vaistai gali išgydyti 95–98% lėtinių infekcijų. |
Kaip hepatito C infekcija veikia organizmą?
Hepatito C infekcija turi keletą stadijų.
Inkubacinis laikotarpis
Kai pirmą kartą užsikrečiama virusu, prasideda inkubacinis laikotarpis, kai virusas dauginasi organizme. Virusas dauginasi tol, kol pasiekia slenkstį, kai organizmas atpažįsta infekciją. Tuomet įsijungia imuninė sistema, ir pradeda pasireikšti simptomai.
Ūminė infekcija
Hepatito C inkubacinis laikotarpis gali trukti nuo dviejų savaičių iki šešių mėnesių. Ūminė infekcijos stadija prasideda, kai imuninė sistema įsijungia. Tai ir tas laikas, kai gali pradėti pasireikšti simptomai. Dauguma virusinių infekcijų ūminėje stadijoje sukelia ligos simptomus, tokius kaip karščiavimas ir uždegimas organizme. Su hepatitu uždegimas daugiausia vyksta kepenyse, ir jūs galite to nepastebėti.
Tik 20% žmonių, sergančių ūminiu hepatitu C, turi simptomų. Žmonės, kuriems pasireiškia simptomai, gali gydyti infekciją antivirusiniais vaistais. Tačiau dauguma žmonių nejaučia simptomų ir nesikreipia gydymo. Ūminė stadija trunka iki trijų mėnesių. Per šį laikotarpį iki 20% žmonių sėkmingai išvalo virusą iš savo organizmo.
Lėtinė infekcija
Dauguma žmonių (80%) nesugeba patys išvalyti viruso ir vystosi ilgalaikė lėtinė infekcija. Tai reiškia, kad jų kepenys nuolat uždegusios ir patinusios. Lėtinis hepatitas sukelia kepenų pažeidimą, vadinamą ciroze. Nuolatinis kepenų uždegimas galiausiai sukelia randėjimą.
Cirozė progresuoja lėtai per kelis dešimtmečius. Jei jūsų kepenys jau buvo pažeistos dėl kitų priežasčių, pavyzdžiui, piktnaudžiavimo alkoholiu, progresas gali būti greitesnis. Jei jūsų kepenys yra geresnės būklės, procesas gali būti lėtesnis. Galutinis rezultatas yra tas, kad randinis audinys neleidžia kepenims tinkamai funkcionuoti. Cirozės rizika nuo lėtinės hepatito C infekcijos yra apie 25% po 20 metų.
Simptomai ir priežastys
Kaip užsikrečiama hepatitu C?
Hepatito C virusas (HCV) plinta per kontaktą su krauju. Infekcija perduodama, kai užsikrėtusio asmens kraujas patenka į sveiko žmogaus kūną. JAV dažniausiai tai nutinka, kai žmonės dalijasi adatomis intraveniniams narkotikams švirkšti. Tačiau yra daugybė kitų atsitiktinių būdų, kaip galite susidurti su kito žmogaus krauju.
Pavyzdžiui:
- Poveikis adatoms ar aštriems daiktams darbe, ypač sveikatos priežiūros srityje.
- Tatuiruotės ar kūno auskarų vėrimas, naudojant nesterilizuotą įrangą.
- Dalijimasis skustuvu ar dantų šepetėliu su kažkuo, kas galėjo kraujuoti jį naudodamas.
- Rečiau per lytinius santykius, kuriuose atsiranda kraujo kontaktas.
Prieš 1992 m. hepatitas C dažnai buvo perduodamas per kraujo perpylimus ir organų transplantacijas. Dabar sveikatos priežiūros specialistai reguliariai tikrina, ar donoruose nėra viruso, prieš naudodami kraują ar organus. Nors ši priežastis nebėra pavojus, gydytojai rekomenduoja visiems, kurie prieš 1992 m. gavo kraujo perpylimą ar organų transplantaciją, pasitikrinti dėl HCV.
Kas dažniausiai paveiktas hepatito C infekcijos?
Labiau tikėtina, kad užsikrėsite hepatitu C, jei:
- Vartojate intraveninius narkotikus.
- Turite ŽIV.
- Gavote kraujo perpylimą ar organų transplantaciją prieš 1992 m.
- Gavote kraujo krešėjimo faktorių dėl hemofilijos prieš 1987 m.
- Gimėte tarp 1945 ir 1965 m.
- Gimėte motinai, sergančiai hepatitu C.
Kokie yra hepatito C simptomai?
Dauguma žmonių neturi jokių simptomų. Maža dalis gali turėti simptomų ūminės infekcijos metu. Simptomai gali būti neaiškūs, panašūs į gripo požymius, arba primenantys kepenų ligos simptomus, įskaitant pilvo skausmą ir geltą. Vėliau galite pastebėti simptomus, kai kepenų liga pasiekia pažengusią stadiją ir kepenys pradeda nebeveikti.
Kokie yra ankstyvieji hepatito C įspėjamieji ženklai?
Ūminiai hepatito C infekcijos simptomai gali priminti gripo simptomus, tokius kaip:
- Karščiavimas.
- Nuovargis.
- Kūno skausmai.
- Apetito praradimas.
Jie taip pat gali priminti ūminio kepenų nepakankamumo simptomus, tokius kaip:
- Gelta (šviesios odos ir akių baltymų pageltimas).
- Pilvo skausmas (ypač viršutiniame dešiniajame kvadrante).
- Pykinimas ir vėmimas.
- Tamsiai spalvotas šlapimas ir šviesios išmatos.
Kokie yra pažengusios kepenų ligos simptomai?
Jei nepastebite ankstyvųjų įspėjamųjų simptomų, galite turėti vėlesnius hepatito įspėjamuosius ženklus, kai pradėsite patirti cirozės poveikį po daugelio metų lėtinės infekcijos. Jūs galite patirti visus minėtus simptomus ir taip pat pastebėti:
- Skysčio kaupimąsi rankose ir kojose (edema).
- Skysčio kaupimąsi pilve (ascitas).
- Niežulį.
- Neaiškų svorio netekimą.
- Lengvą mėlynių susidarymą ir kraujavimą.
- Sunkumą mąstant ar prisimenant, sumišimą (hepatinė encefalopatija).
Diagnozė ir tyrimai
Kaip diagnozuojamas hepatitas C?
Patikra dėl hepatito C infekcijos prasideda nuo paprasto kraujo tyrimo. Gydytojas paims nedidelį kraujo mėginį iš venos ir išsiųs jį į laboratoriją. Jei užsikrėtėte virusu, jūsų kraujyje bus hepatito C antikūnų. Jei testas teigiamas, gydytojas atliks papildomus kraujo tyrimus.
Kokie kiti medicininiai tyrimai bus atliekami?
Jei testas teigiamas dėl lėtinės hepatito C infekcijos, gydytojas norės įvertinti jūsų kepenų būklę. Jie norės sužinoti, kiek kepenų audinio jau yra pakeista rando audiniu. Tyrimai gali apimti:
- Kepenų funkcijos tyrimai. Tai serija kraujo tyrimų, kurie įvertina kepenų būklę.
- Elastografija. Neinvazinis vaizdinis tyrimas, matuojantis kepenų audinio standumą ar fibrozę, naudojant ultragarsą arba MRT.
- Kepenų biopsija. Kai kitų tyrimų rezultatai nėra galutiniai, gydytojas gali paimti audinio mėginį iš kepenų laboratoriniam tyrimui. Tai dažniausiai atliekama per pilvo sienelę įkišant tuščiavidurę adatą.
Gydymas ir valdymas
Ar hepatitas C praeina savaime?
Jis paprastai nepraeina be gydymo, bet kartais gali praeiti. Jei esate tarp nedaugelio žmonių, kurie sugeba savaime pašalinti virusą, tai įvyks ūminės infekcijos stadijos metu. Jei tai pavyksta, lėtinė infekcija neišsivystys.
Jei turite lėtinę infekciją, tai reiškia, kad virusas aplenkė jūsų imuninę sistemą, ir jums reikės pagalbos jį pašalinti. Laimei, nauji antivirusiniai vaistai leidžia tai padaryti. Šiuolaikiniai antivirusiniai vaistai gali išgydyti 95–98% lėtinių hepatito C infekcijų per 8–24 savaites.
Koks yra hepatito C gydymas?
Dabar yra daugybė vaistų, skirtų hepatitui C gydyti. Skirtingi vaistai rekomenduojami gydyti skirtingoms viruso atmainoms. Gydymo trukmė gali priklausyti nuo jūsų bendros būklės ir turimos viruso atmainos (genotipo). Kai kurios atmainos geriau reaguoja į gydymą nei kitos.
Patvirtinti vaistai hepatito C gydymui yra:
- Sofosbuviras (Sovaldi®).
- Ledipasviras/sofosbuviras (Harvoni®).
- Simepreviras (Olysio®).
- Paritapreviras/ombitasviras/ritonaviras/dasabuviras (Viekira Pak®).
- Daklatasviras (Daklinza®).
- Elbasviras/grazopreviras (Zepatier®).
- Sofosbuviras/velpatasviras (Epclusa®).
- Glecapreviras/pibrentasviras (Mavyret®).
- Sofosbuviras/velpatasviras/voxilapreviras (Vosevi®).
- Ombitasviras/paritapreviras/ritonaviras (Technivie®).
- Ribavirinas (RibaPak®).
- Peginterferonas alfa-2a/2b (Pegasys®/PEG-Intron®).
Ar man reikės papildomo gydymo?
Jei jau turite pažengusią kepenų ligą (cirozę), infekcijos išgydymas gali nepakakti. Jums gali reikėti kepenų transplantacijos. Net jei turite gauti naujas kepenis, išgydyti hepatitą C vis tiek svarbu siekiant apsaugoti naująsias kepenis.
Prevencija
Ar yra hepatito C vakcina?
Šiuo metu nėra veiksmingos vakcinos, skirtos hepatitui C išvengti. Tyrėjai ilgą laiką dirbo šiuo klausimu, tačiau hepatitas C pasirodė sunkiai išvengiamas dėl daugelio jo variacijų ir spartaus mutavimosi. Vienintelis veiksmingas būdas išvengti hepatito C infekcijos yra vengti kontakto su užkrėstu krauju, ypač nenaudoti bendrų adatų ar švirkštų.
Perspektyva ir prognozė
Kokia yra prognozė žmonėms, sergantiems lėtiniu hepatitu C?
Nauji vaistai leidžia padaryti prognozę daug šviesesnę. Net jei daugelį metų sergate lėtine infekcija, dabar galite ją išgydyti per kelias savaites. Vis dėlto kai kurie žmonės gali turėti didelę kepenų žalą prieš pradėdami gydymą.
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Tennessee Advisory Fee on Intergovernmental Relations.
Bonuses are however not guaranteed and may not be there in future.
Since this measure is affected by the width of the rim, the measurement is for the tire when it’s on its meant rim measurement.
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The latter kills Jedi Grasp Qui-Gon Jinn however is defeated by his padawan Obi-Wan Kenobi and is presumed dead.
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You could also be there because you’re young and also you crave the excitement of metropolis life.
Many investments trade on exchanges and their prices depend on the supply and demand caused by millions of investors that buy or sell the instruments at any given point in time.
It was slightly more expensive than the Cadillac Sixty-Two extended-deck hardtop sedan, and a couple inches longer, to boot.
The ranking of the next desk is based on the realm (or square mileage) of every group within Larger Pittston.
This will likely result in a well-thought-out, broadly diversified portfolio that features diverse asset classes and investment styles, and in addition balances risk and safety, growth as well as revenue, and domestic and international exposure.
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In 1979 the European Financial System (EMS) was established and replaced ‘the snake’ and the EMCF took charge of the same tasks within the European Monetary Techniques’ European Alternate Price Mechanism (ERM).
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Investment decisions – Regarding the long and short term investment decisions.
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That is, Arthur Fleck, who here makes a severe distinction between himself as a civilian and himself as a “Joker,” is a deeply disturbed particular person whose warped imagination could effectively envision his existence as being inside a present of some kind.
By 2003, demand for the trading cards was so great that Nintendo took over publishing them alongside the video games.
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Bonded urethane carpet padding is the result of a significant recycling effort within the industry.
When may you be higher off renting than shopping for a house?
The left hand light reveals the angel of God in full armour with a flaming sword, and angels above, because the Israelites cross the Crimson Sea.
Via proactive steps like these, residents of this state can guarantee their houses remain secure and safe regardless of the ever-altering climate.
Given the Samsung group’s top line, a minor proportion improvement in cost or top line could be a number of times the value of the monetary return of the particular investment.
Hint components play a necessary position in giving shade.
With a lack of personal savings to enhance your retirement funds, you will find it virtually impossible to enjoy anything above the bare minimum standards of living.
There can be tax implications on trading transactions.
», Terrorism and Political Violence, vol.
An occasion supervisor is probably the most accountable person in the group and at the helm of planning and executing the occasion.
The breed has continued as one of the more popular, longer than any other breed.
Business restructuring: When business mergers happen there is a need to fully restructure the newly formed firm.
How many of us could afford a home if we had to come up with a check for half of its value just to close?
Tones of sand and blue-grey collectively are like a day at the shore.
Whereas the world has moved on to laptops and smartphones, I discover myself drawn back to the charm of the Electric Typewriters.
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A 2018 survey by The Workforce Institute discovered that 45 p.c of global employees think it should only take 5 hours a day to do their job, and 35 percent would take a 20-p.c pay cut if they might work one much less day every week.
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Delta: Option Delta measures the change in choice value per unit change in underlying asset price.
Since inflation lowers actual wages, Keynesians view inflation as the solution to involuntary unemployment.
Single stock futures make sense if you like to short stocks.
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Alternative approaches to carbon pricing embrace cap-and-commerce systems, where emissions permits are traded amongst companies, and carbon offset programs, where emissions are compensated via investments in carbon discount tasks, offering flexibility and diversity in combating climate change.
On 26 October 2011, Rodriguez scored his second objective for the membership, netting his side’s second from the penalty spot, in a 2-zero win over FC Thun.
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The first Spherical draw is because of be televised on BBC2 at roughly 7pm on Monday, October 26.
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The subsequent week, Barr appeared on Fox Information, where he criticized the United States Treasury Department’s plan to assist Freddie Mac and Fannie Mae.
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Additionally, the pattern nowadays has turn into to go for international areas and worldwide financial centers so that the enterprise is promoted to a big extent.
One instance is Stockholm-Sundsvall, with one day by day departure, calling at Arlanda, Uppsala, Gävle, Söderhamn, Hudiksvall and Sundsvall.
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The town council of Hitzacker has 17 councillors.
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However America was the first nation to enshrine these ideals as the premise of a government.
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Operation Fortitude was one of the grandest and most successful misinformation campaigns ever conducted.
These lawsuits involved large groups of people and often resulted in settlements that the defendant simply could not afford to pay in one lump sum.
The hyperinflation crisis triggered protests, riots, looting and a normal decline of the federal government popularity among the public.
Make them seasonal or use a pattern that works any time of yr on your dinner visitors.
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If you’re a farmer and also you block a street, the prime minister might join you.
Ocean Journey opened on April 29, 2005.
You need to apply for certification in the state where you want to work.
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He inspired governments to adjust monetary policies (interest charges and the availability or amount of cash circulating) and fiscal insurance policies (authorities spending and taxes) to boost demand.
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They use these particulars in figuring out the extent of threat of providing coverage to a person.
There’s no lowering the price by saying, for instance, „I don’t want Garage Band.” And with premium software by default, it’s easy to see why the base model Mac sports a higher price tag than a basic PC.
Take an anti-inflammatory drug.
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She was preceded in death by her son, Ross Thomas Bishop.
Without figuring out when it’s the correct time to each go right into a market and exit a marketplace, you might end up dropping tons of cash studying how to buy and sell commodities.
Some ice rinks, together with the well-known Rockefeller Middle Ice Rink in New York, are solely open seasonally whereas different local rinks are reserved for classes, so be certain to name forward.